SINTEF, department of Biotechnology and Nanomedicine
Several brain pathologies are associated with oxidative stress and dysfunctional DNA damage responses. We’re broadly working on developing therpeutics to enhance resistance against oxidative stress, by enhancing genome stability, high-content imaging, and high-throughput drug combination screening.
Our team has access to advanced highly automated high-throughput and high-content systems for enzyme- and cell-based assays. Our research focuses on several axes with high relevance for central nervous system disorders:
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1. Developing small-molecule inhibitors to target cellular responses to oxidative stress, with a particular focus on genome stability pathways.
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2. Advanced profiling of cellular responses to genetic or pharmacological alterations, including morphological profiling (i.e., the Cell Painting assay).
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3. Precision medicine approaches using functional assays of patient-derived cells, using automated, miniteurized and parallelized cultures to assess e.g., the effect of drug combinations on cells.
